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ImmunityBio Inc pd-l1 t-hank
Pd L1 T Hank, supplied by ImmunityBio Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/pd-l1+t-hank/pd+l1+t+hank/nct06239220-7-3-0
Average 90 stars, based on 1 article reviews
pd-l1 t-hank - by Bioz Stars, 2026-09
90/100 stars

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Related Articles

Modification:

Article Title: Next Generation Natural Killer Cells for Cancer Immunotherapy
Article Snippet: , PD-L1 , Pancreatic Cancer , NK-92 cell line , PD-L1 t-haNK , N-803 , ImmunityBio, Inc. , Phase 2 , NCT04390399.

Article Title: Harnessing the Power of NK Cell Receptor Engineering as a New Prospect in Cancer Immunotherapy
Article Snippet: PD-1/PD-L1 , QUILT-3.055, Anti-PD-1, Anti-PD-L1, PD-L1 t-haNK , Cancers previously treated with PD-1/PD-L1 Immune Checkpoint Inhibitors , NK-92 , ImmunityBio, Inc. , Anchorage AK, Hot Springs AR, El Segundo CA USA , Active, not recruiting , II , 2018 , Initial Outcomes: N803 shows low toxicity and promising efficacy in halting progression and inducing durable stable disease in patients who had previously progressed on various tumor types and CPI regimens , NCT03228667.

Article Title: Harnessing the Power of NK Cell Receptor Engineering as a New Prospect in Cancer Immunotherapy
Article Snippet: PD-L1 , QUILT-3.064, PD-L1 t-haNK , Advanced or metastatic solid tumors , NK-92 , ImmunityBio, Inc. , El Segundo CA USA , Active, not recruiting , I , 2019 , - , NCT04050709.

Article Title: Harnessing the Power of NK Cell Receptor Engineering as a New Prospect in Cancer Immunotherapy
Article Snippet: PD-L1 , Sacituzumab, PD-L1 t-haNK, N-803 , Advanced Triple Negative Breast Cancer , NK-92 , ImmunityBio, Inc. , Newport Beach CA USA , Terminated , I/II , 2021 , Low enrollment , NCT04927884.

Article Title: Research progress of interleukin-15 in cancer immunotherapy
Article Snippet: , , NCT04927884 , ImmunityBio, Inc , Triple negative breast cancer (TNBC) after at least 2 prior treatments for metastatic disease , Combine with PD-L1 t-haNK, sacituzumab govitecan-hziy and drug: cyclophosphamide , Ib/II , 2021.9.27 , 2024.1.

Article Title: Harnessing the Power of NK Cell Receptor Engineering as a New Prospect in Cancer Immunotherapy
Article Snippet: PD-L1 , PD-L1 t-haNK, N-803, Aldoxorubicin , Pancreatic Cancer , NK-92 , ImmunityBio, Inc. , El Segundo CA, Newport beach CA, East Brunswick NJ USA , Active, not recruiting , II , 2020 , - , NCT04390399.

Article Title: A Phase 2 Trial of PD-L1 t-haNK, N-803 IL-15 Superagonist (Anktiva), and Cetuximab for Immunotherapy-treated Patients With Recurrent, Metastatic HNSCC (QUILT-505)
Article Snippet: ImmunityBio is supplying PD-L1 t-haNK and N-803 for the study.

Control:

Article Title: Next Generation Natural Killer Cells for Cancer Immunotherapy
Article Snippet: , PD-L1 , Pancreatic Cancer , NK-92 cell line , PD-L1 t-haNK , N-803 , ImmunityBio, Inc. , Phase 2 , NCT04390399.

Article Title: Harnessing the Power of NK Cell Receptor Engineering as a New Prospect in Cancer Immunotherapy
Article Snippet: PD-1/PD-L1 , QUILT-3.055, Anti-PD-1, Anti-PD-L1, PD-L1 t-haNK , Cancers previously treated with PD-1/PD-L1 Immune Checkpoint Inhibitors , NK-92 , ImmunityBio, Inc. , Anchorage AK, Hot Springs AR, El Segundo CA USA , Active, not recruiting , II , 2018 , Initial Outcomes: N803 shows low toxicity and promising efficacy in halting progression and inducing durable stable disease in patients who had previously progressed on various tumor types and CPI regimens , NCT03228667.

Article Title: Harnessing the Power of NK Cell Receptor Engineering as a New Prospect in Cancer Immunotherapy
Article Snippet: PD-L1 , QUILT-3.064, PD-L1 t-haNK , Advanced or metastatic solid tumors , NK-92 , ImmunityBio, Inc. , El Segundo CA USA , Active, not recruiting , I , 2019 , - , NCT04050709.

Article Title: Harnessing the Power of NK Cell Receptor Engineering as a New Prospect in Cancer Immunotherapy
Article Snippet: PD-L1 , Sacituzumab, PD-L1 t-haNK, N-803 , Advanced Triple Negative Breast Cancer , NK-92 , ImmunityBio, Inc. , Newport Beach CA USA , Terminated , I/II , 2021 , Low enrollment , NCT04927884.

Article Title: Research progress of interleukin-15 in cancer immunotherapy
Article Snippet: , , NCT04927884 , ImmunityBio, Inc , Triple negative breast cancer (TNBC) after at least 2 prior treatments for metastatic disease , Combine with PD-L1 t-haNK, sacituzumab govitecan-hziy and drug: cyclophosphamide , Ib/II , 2021.9.27 , 2024.1.

Article Title: Harnessing the Power of NK Cell Receptor Engineering as a New Prospect in Cancer Immunotherapy
Article Snippet: PD-L1 , PD-L1 t-haNK, N-803, Aldoxorubicin , Pancreatic Cancer , NK-92 , ImmunityBio, Inc. , El Segundo CA, Newport beach CA, East Brunswick NJ USA , Active, not recruiting , II , 2020 , - , NCT04390399.

Article Title: A Phase 2 Trial of PD-L1 t-haNK, N-803 IL-15 Superagonist (Anktiva), and Cetuximab for Immunotherapy-treated Patients With Recurrent, Metastatic HNSCC (QUILT-505)
Article Snippet: ImmunityBio is supplying PD-L1 t-haNK and N-803 for the study.

Activity Assay:

Article Title: Next Generation Natural Killer Cells for Cancer Immunotherapy
Article Snippet: , PD-L1 , Pancreatic Cancer , NK-92 cell line , PD-L1 t-haNK , N-803 , ImmunityBio, Inc. , Phase 2 , NCT04390399.

Article Title: Harnessing the Power of NK Cell Receptor Engineering as a New Prospect in Cancer Immunotherapy
Article Snippet: PD-1/PD-L1 , QUILT-3.055, Anti-PD-1, Anti-PD-L1, PD-L1 t-haNK , Cancers previously treated with PD-1/PD-L1 Immune Checkpoint Inhibitors , NK-92 , ImmunityBio, Inc. , Anchorage AK, Hot Springs AR, El Segundo CA USA , Active, not recruiting , II , 2018 , Initial Outcomes: N803 shows low toxicity and promising efficacy in halting progression and inducing durable stable disease in patients who had previously progressed on various tumor types and CPI regimens , NCT03228667.

Article Title: Harnessing the Power of NK Cell Receptor Engineering as a New Prospect in Cancer Immunotherapy
Article Snippet: PD-L1 , QUILT-3.064, PD-L1 t-haNK , Advanced or metastatic solid tumors , NK-92 , ImmunityBio, Inc. , El Segundo CA USA , Active, not recruiting , I , 2019 , - , NCT04050709.

Article Title: Harnessing the Power of NK Cell Receptor Engineering as a New Prospect in Cancer Immunotherapy
Article Snippet: PD-L1 , Sacituzumab, PD-L1 t-haNK, N-803 , Advanced Triple Negative Breast Cancer , NK-92 , ImmunityBio, Inc. , Newport Beach CA USA , Terminated , I/II , 2021 , Low enrollment , NCT04927884.

Article Title: Research progress of interleukin-15 in cancer immunotherapy
Article Snippet: , , NCT04927884 , ImmunityBio, Inc , Triple negative breast cancer (TNBC) after at least 2 prior treatments for metastatic disease , Combine with PD-L1 t-haNK, sacituzumab govitecan-hziy and drug: cyclophosphamide , Ib/II , 2021.9.27 , 2024.1.

Article Title: Harnessing the Power of NK Cell Receptor Engineering as a New Prospect in Cancer Immunotherapy
Article Snippet: PD-L1 , PD-L1 t-haNK, N-803, Aldoxorubicin , Pancreatic Cancer , NK-92 , ImmunityBio, Inc. , El Segundo CA, Newport beach CA, East Brunswick NJ USA , Active, not recruiting , II , 2020 , - , NCT04390399.

Article Title: A Phase 2 Trial of PD-L1 t-haNK, N-803 IL-15 Superagonist (Anktiva), and Cetuximab for Immunotherapy-treated Patients With Recurrent, Metastatic HNSCC (QUILT-505)
Article Snippet: ImmunityBio is supplying PD-L1 t-haNK and N-803 for the study.

Biomarker Discovery:

Article Title: Next Generation Natural Killer Cells for Cancer Immunotherapy
Article Snippet: , PD-L1 , Pancreatic Cancer , NK-92 cell line , PD-L1 t-haNK , N-803 , ImmunityBio, Inc. , Phase 2 , NCT04390399.

Article Title: Harnessing the Power of NK Cell Receptor Engineering as a New Prospect in Cancer Immunotherapy
Article Snippet: PD-1/PD-L1 , QUILT-3.055, Anti-PD-1, Anti-PD-L1, PD-L1 t-haNK , Cancers previously treated with PD-1/PD-L1 Immune Checkpoint Inhibitors , NK-92 , ImmunityBio, Inc. , Anchorage AK, Hot Springs AR, El Segundo CA USA , Active, not recruiting , II , 2018 , Initial Outcomes: N803 shows low toxicity and promising efficacy in halting progression and inducing durable stable disease in patients who had previously progressed on various tumor types and CPI regimens , NCT03228667.

Article Title: Harnessing the Power of NK Cell Receptor Engineering as a New Prospect in Cancer Immunotherapy
Article Snippet: PD-L1 , QUILT-3.064, PD-L1 t-haNK , Advanced or metastatic solid tumors , NK-92 , ImmunityBio, Inc. , El Segundo CA USA , Active, not recruiting , I , 2019 , - , NCT04050709.

Article Title: Harnessing the Power of NK Cell Receptor Engineering as a New Prospect in Cancer Immunotherapy
Article Snippet: PD-L1 , Sacituzumab, PD-L1 t-haNK, N-803 , Advanced Triple Negative Breast Cancer , NK-92 , ImmunityBio, Inc. , Newport Beach CA USA , Terminated , I/II , 2021 , Low enrollment , NCT04927884.

Article Title: Research progress of interleukin-15 in cancer immunotherapy
Article Snippet: , , NCT04927884 , ImmunityBio, Inc , Triple negative breast cancer (TNBC) after at least 2 prior treatments for metastatic disease , Combine with PD-L1 t-haNK, sacituzumab govitecan-hziy and drug: cyclophosphamide , Ib/II , 2021.9.27 , 2024.1.

Article Title: Harnessing the Power of NK Cell Receptor Engineering as a New Prospect in Cancer Immunotherapy
Article Snippet: PD-L1 , PD-L1 t-haNK, N-803, Aldoxorubicin , Pancreatic Cancer , NK-92 , ImmunityBio, Inc. , El Segundo CA, Newport beach CA, East Brunswick NJ USA , Active, not recruiting , II , 2020 , - , NCT04390399.

Article Title: A Phase 2 Trial of PD-L1 t-haNK, N-803 IL-15 Superagonist (Anktiva), and Cetuximab for Immunotherapy-treated Patients With Recurrent, Metastatic HNSCC (QUILT-505)
Article Snippet: ImmunityBio is supplying PD-L1 t-haNK and N-803 for the study.



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ImmunityBio Inc pd-l1 t-hank
Pd L1 T Hank, supplied by ImmunityBio Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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ImmunityBio Inc pd-l1-specific chimeric antigen receptor engineered high affinity natural killer cells pd-l1 t-hanks
Six chordoma cell lines; established from 3 from clival tumor patients (UM-Chor1, MUG-CC1, UM-Chor5), and 3 sacral tumor patients (JHC7, U-CH1, U-CH2) were analyzed by flow cytometry to quantify expression surface markers MHC-I/HLA-A,B,C, <t> PD-L1, </t> and EGFR. Cell surface expression of each marker is reported in % positive cells and MFI.
Pd L1 Specific Chimeric Antigen Receptor Engineered High Affinity Natural Killer Cells Pd L1 T Hanks, supplied by ImmunityBio Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Six chordoma cell lines; established from 3 from clival tumor patients (UM-Chor1, MUG-CC1, UM-Chor5), and 3 sacral tumor patients (JHC7, U-CH1, U-CH2) were analyzed by flow cytometry to quantify expression surface markers MHC-I/HLA-A,B,C,  PD-L1,  and EGFR. Cell surface expression of each marker is reported in % positive cells and MFI.

Journal: Cancer research communications

Article Title: Combinatorial Natural Killer Cell–based Immunotherapy Approaches Selectively Target Chordoma Cancer Stem Cells

doi: 10.1158/2767-9764.crc-21-0020

Figure Lengend Snippet: Six chordoma cell lines; established from 3 from clival tumor patients (UM-Chor1, MUG-CC1, UM-Chor5), and 3 sacral tumor patients (JHC7, U-CH1, U-CH2) were analyzed by flow cytometry to quantify expression surface markers MHC-I/HLA-A,B,C, PD-L1, and EGFR. Cell surface expression of each marker is reported in % positive cells and MFI.

Article Snippet: Immune reagents and NK cells An anti-PD-L1 antibody (N-601), an IL-15/IL-15r superagonist (N-803), and the PD-L1-specific chimeric antigen receptor engineered high affinity natural killer cells (PD-L1 t-haNKs) were provided by ImmunityBio under a Cooperative Research and Development Agreement (CRADA) with the National Cancer Institute (NCI) of the National Institutes of Health (NIH).

Techniques: Flow Cytometry, Expressing, Marker

Two chordoma cell lines (UM-Chor1, JHC7) were used as targets for PD-L1 t-haNK cells in 111In-release killing assays. (A) Chordoma cells were analyzed by flow cytometry for PD-L1 expression after 24-hour co-incubation with IFNγ on the same day as killing assays. Cell surface expression of PD-L1 quantified by flow cytometry is reported in % positive cells and MFI. Bold values denote an increase of > 30% relative to untreated control cells. (B) Chordoma cells were co-incubated with IFNγ or left untreated as controls for 24 hours before being used as targets for PD-L1 t-haNK cells. All E:T ratios are 20:1. Statistical analyses were done by one-way ANOVA with Tukey’s multiple comparisons test. *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001, ****P ≤ 0.0001. Results shown are the means ± SEM of technical triplicate measurements and are representative of three independent experiments.

Journal: Cancer research communications

Article Title: Combinatorial Natural Killer Cell–based Immunotherapy Approaches Selectively Target Chordoma Cancer Stem Cells

doi: 10.1158/2767-9764.crc-21-0020

Figure Lengend Snippet: Two chordoma cell lines (UM-Chor1, JHC7) were used as targets for PD-L1 t-haNK cells in 111In-release killing assays. (A) Chordoma cells were analyzed by flow cytometry for PD-L1 expression after 24-hour co-incubation with IFNγ on the same day as killing assays. Cell surface expression of PD-L1 quantified by flow cytometry is reported in % positive cells and MFI. Bold values denote an increase of > 30% relative to untreated control cells. (B) Chordoma cells were co-incubated with IFNγ or left untreated as controls for 24 hours before being used as targets for PD-L1 t-haNK cells. All E:T ratios are 20:1. Statistical analyses were done by one-way ANOVA with Tukey’s multiple comparisons test. *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001, ****P ≤ 0.0001. Results shown are the means ± SEM of technical triplicate measurements and are representative of three independent experiments.

Article Snippet: Immune reagents and NK cells An anti-PD-L1 antibody (N-601), an IL-15/IL-15r superagonist (N-803), and the PD-L1-specific chimeric antigen receptor engineered high affinity natural killer cells (PD-L1 t-haNKs) were provided by ImmunityBio under a Cooperative Research and Development Agreement (CRADA) with the National Cancer Institute (NCI) of the National Institutes of Health (NIH).

Techniques: Flow Cytometry, Expressing, Incubation, Control

CellTrace Violet-stained UM-Chor1 cells were used as targets for healthy donor NK cells in a flow cytometry-based killing assay. (A) CSC and non-CSC subpopulations were identified using the gating strategy described. (B) UM-Chor1 cells were co-incubated with N-601 or isotype control antibody and NK cells were treated with N-803 where indicated. CSC and non-CSC cell death through N-601-mediated ADCC by untreated or N-803-treated NK cells were evaluated via flow cytometry using a live/dead fixable cell stain exclusion method. (Cand D) Flow cytometry was used to quantify expression of HLA-A,B,C, MICA/B, B7-H6, and PD-L1 expression on CSC and non-CSC UM-Chor1 cells. Cell surface expression of each marker is reported in % positive cells and MFI. Bold values denote an increase of > 20% when comparing CSC vs. non-CSC. All E:T ratios are 5:1. Statistical analyses were done by one-way ANOVA with Tukey’s multiple comparisons test. *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001, ****P ≤ 0.0001. Results shown are the means ± SEM of technical quadruplicate measurements and are representative of two independent experiments.

Journal: Cancer research communications

Article Title: Combinatorial Natural Killer Cell–based Immunotherapy Approaches Selectively Target Chordoma Cancer Stem Cells

doi: 10.1158/2767-9764.crc-21-0020

Figure Lengend Snippet: CellTrace Violet-stained UM-Chor1 cells were used as targets for healthy donor NK cells in a flow cytometry-based killing assay. (A) CSC and non-CSC subpopulations were identified using the gating strategy described. (B) UM-Chor1 cells were co-incubated with N-601 or isotype control antibody and NK cells were treated with N-803 where indicated. CSC and non-CSC cell death through N-601-mediated ADCC by untreated or N-803-treated NK cells were evaluated via flow cytometry using a live/dead fixable cell stain exclusion method. (Cand D) Flow cytometry was used to quantify expression of HLA-A,B,C, MICA/B, B7-H6, and PD-L1 expression on CSC and non-CSC UM-Chor1 cells. Cell surface expression of each marker is reported in % positive cells and MFI. Bold values denote an increase of > 20% when comparing CSC vs. non-CSC. All E:T ratios are 5:1. Statistical analyses were done by one-way ANOVA with Tukey’s multiple comparisons test. *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001, ****P ≤ 0.0001. Results shown are the means ± SEM of technical quadruplicate measurements and are representative of two independent experiments.

Article Snippet: Immune reagents and NK cells An anti-PD-L1 antibody (N-601), an IL-15/IL-15r superagonist (N-803), and the PD-L1-specific chimeric antigen receptor engineered high affinity natural killer cells (PD-L1 t-haNKs) were provided by ImmunityBio under a Cooperative Research and Development Agreement (CRADA) with the National Cancer Institute (NCI) of the National Institutes of Health (NIH).

Techniques: Staining, Flow Cytometry, Incubation, Control, Expressing, Marker